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Splice Variants of the Forkhead Box Protein AFX Exhibit Dominant Negative Activity and Inhibit AFXα-Mediated Tumor Cell Apoptosis
BACKGROUND: Loss-of-function in the apoptosis-inducing genes is known to facilitate tumorigenesis. AFX (FOXO4), a member of forkhead transcription factors functions as a tumor suppressor and has 2 isoforms, AFXα (505 a.a.) and AFXζ (450 a.a.). In human cancer cells, we identified an N-terminally del...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447181/ https://www.ncbi.nlm.nih.gov/pubmed/18648506 http://dx.doi.org/10.1371/journal.pone.0002743 |