ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data

We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary res...

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Detalles Bibliográficos
Autores principales: Skilling, John, Denny, Richard, Richardson, Keith, Young, Phillip, McKenna, Thérèse, Campuzano, Iain, Ritchie, Mark
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447321/
https://www.ncbi.nlm.nih.gov/pubmed/18629038
http://dx.doi.org/10.1002/cfg.370
Descripción
Sumario:We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary results of our tuning efforts.

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