ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data

We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary res...

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Detalles Bibliográficos
Autores principales: Skilling, John, Denny, Richard, Richardson, Keith, Young, Phillip, McKenna, Thérèse, Campuzano, Iain, Ritchie, Mark
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447321/
https://www.ncbi.nlm.nih.gov/pubmed/18629038
http://dx.doi.org/10.1002/cfg.370
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author Skilling, John
Denny, Richard
Richardson, Keith
Young, Phillip
McKenna, Thérèse
Campuzano, Iain
Ritchie, Mark
author_facet Skilling, John
Denny, Richard
Richardson, Keith
Young, Phillip
McKenna, Thérèse
Campuzano, Iain
Ritchie, Mark
author_sort Skilling, John
collection PubMed
description We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary results of our tuning efforts.
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spelling pubmed-24473212008-07-14 ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data Skilling, John Denny, Richard Richardson, Keith Young, Phillip McKenna, Thérèse Campuzano, Iain Ritchie, Mark Comp Funct Genomics Research Article We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary results of our tuning efforts. Hindawi Publishing Corporation 2004-02 /pmc/articles/PMC2447321/ /pubmed/18629038 http://dx.doi.org/10.1002/cfg.370 Text en Copyright © 2004 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Skilling, John
Denny, Richard
Richardson, Keith
Young, Phillip
McKenna, Thérèse
Campuzano, Iain
Ritchie, Mark
ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data
title ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data
title_full ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data
title_fullStr ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data
title_full_unstemmed ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data
title_short ProbSeq—A Fragmentation Model for Interpretation of Electrospray Tandem Mass Spectrometry Data
title_sort probseq—a fragmentation model for interpretation of electrospray tandem mass spectrometry data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447321/
https://www.ncbi.nlm.nih.gov/pubmed/18629038
http://dx.doi.org/10.1002/cfg.370
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