Looking for Cancer Clues in Publicly Accessible Databases

What started out as a mere attempt to tentatively identify proteins in experimental cancer-related 2D-PAGE maps developed into VIRTUAL2D, a web-accessible repository for theoretical pI/MW charts for 92 organisms. Using publicly available expression data, we developed a collection of tissue-specific...

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Detalles Bibliográficos
Autores principales: Medjahed, Djamel, Lemkin, Peter F., Smythers, Gary W., Munroe, David J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447349/
https://www.ncbi.nlm.nih.gov/pubmed/18629065
http://dx.doi.org/10.1002/cfg.378
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author Medjahed, Djamel
Lemkin, Peter F.
Smythers, Gary W.
Munroe, David J.
author_facet Medjahed, Djamel
Lemkin, Peter F.
Smythers, Gary W.
Munroe, David J.
author_sort Medjahed, Djamel
collection PubMed
description What started out as a mere attempt to tentatively identify proteins in experimental cancer-related 2D-PAGE maps developed into VIRTUAL2D, a web-accessible repository for theoretical pI/MW charts for 92 organisms. Using publicly available expression data, we developed a collection of tissue-specific plots based on differential gene expression between normal and diseased states. We use this comparative cancer proteomics knowledge base, known as the tissue molecular anatomy project (TMAP), to uncover threads of cancer markers common to several types of cancer and to relate this information to established biological pathways.
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spelling pubmed-24473492008-07-14 Looking for Cancer Clues in Publicly Accessible Databases Medjahed, Djamel Lemkin, Peter F. Smythers, Gary W. Munroe, David J. Comp Funct Genomics Research Article What started out as a mere attempt to tentatively identify proteins in experimental cancer-related 2D-PAGE maps developed into VIRTUAL2D, a web-accessible repository for theoretical pI/MW charts for 92 organisms. Using publicly available expression data, we developed a collection of tissue-specific plots based on differential gene expression between normal and diseased states. We use this comparative cancer proteomics knowledge base, known as the tissue molecular anatomy project (TMAP), to uncover threads of cancer markers common to several types of cancer and to relate this information to established biological pathways. Hindawi Publishing Corporation 2004-03 /pmc/articles/PMC2447349/ /pubmed/18629065 http://dx.doi.org/10.1002/cfg.378 Text en Copyright © 2004 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Medjahed, Djamel
Lemkin, Peter F.
Smythers, Gary W.
Munroe, David J.
Looking for Cancer Clues in Publicly Accessible Databases
title Looking for Cancer Clues in Publicly Accessible Databases
title_full Looking for Cancer Clues in Publicly Accessible Databases
title_fullStr Looking for Cancer Clues in Publicly Accessible Databases
title_full_unstemmed Looking for Cancer Clues in Publicly Accessible Databases
title_short Looking for Cancer Clues in Publicly Accessible Databases
title_sort looking for cancer clues in publicly accessible databases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447349/
https://www.ncbi.nlm.nih.gov/pubmed/18629065
http://dx.doi.org/10.1002/cfg.378
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