The Prediction of Membrane Protein Structure and Genome Structural Annotation

New methods, essentially based on hidden Markov models (HMM) and neural networks (NN), can predict the topography of both β-barrel and all-α membrane proteins with high accuracy and a low rate of false positives and false negatives. These methods have been integrated in a suite of programs to filter...

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Detalles Bibliográficos
Autores principales: Martelli, Pier Luigi, Fariselli, Piero, Tasco, Gianluca, Casadio, Rita
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447372/
https://www.ncbi.nlm.nih.gov/pubmed/18629086
http://dx.doi.org/10.1002/cfg.308
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author Martelli, Pier Luigi
Fariselli, Piero
Tasco, Gianluca
Casadio, Rita
author_facet Martelli, Pier Luigi
Fariselli, Piero
Tasco, Gianluca
Casadio, Rita
author_sort Martelli, Pier Luigi
collection PubMed
description New methods, essentially based on hidden Markov models (HMM) and neural networks (NN), can predict the topography of both β-barrel and all-α membrane proteins with high accuracy and a low rate of false positives and false negatives. These methods have been integrated in a suite of programs to filter proteomes of Gram-negative bacteria, searching for new membrane proteins.
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spelling pubmed-24473722008-07-14 The Prediction of Membrane Protein Structure and Genome Structural Annotation Martelli, Pier Luigi Fariselli, Piero Tasco, Gianluca Casadio, Rita Comp Funct Genomics Research Article New methods, essentially based on hidden Markov models (HMM) and neural networks (NN), can predict the topography of both β-barrel and all-α membrane proteins with high accuracy and a low rate of false positives and false negatives. These methods have been integrated in a suite of programs to filter proteomes of Gram-negative bacteria, searching for new membrane proteins. Hindawi Publishing Corporation 2003-07 /pmc/articles/PMC2447372/ /pubmed/18629086 http://dx.doi.org/10.1002/cfg.308 Text en Copyright © 2003 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Martelli, Pier Luigi
Fariselli, Piero
Tasco, Gianluca
Casadio, Rita
The Prediction of Membrane Protein Structure and Genome Structural Annotation
title The Prediction of Membrane Protein Structure and Genome Structural Annotation
title_full The Prediction of Membrane Protein Structure and Genome Structural Annotation
title_fullStr The Prediction of Membrane Protein Structure and Genome Structural Annotation
title_full_unstemmed The Prediction of Membrane Protein Structure and Genome Structural Annotation
title_short The Prediction of Membrane Protein Structure and Genome Structural Annotation
title_sort prediction of membrane protein structure and genome structural annotation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447372/
https://www.ncbi.nlm.nih.gov/pubmed/18629086
http://dx.doi.org/10.1002/cfg.308
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