Understanding and Predicting Protein Assemblies With 3D Structures

Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for interaction discovery, little attention has been paid to one of the best sources of data: complexes of known three-dimensional (3D) stru...

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Detalles Bibliográficos
Autores principales: Aloy, Patrick, Russell, Robert B.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447374/
https://www.ncbi.nlm.nih.gov/pubmed/18629088
http://dx.doi.org/10.1002/cfg.310
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author Aloy, Patrick
Russell, Robert B.
author_facet Aloy, Patrick
Russell, Robert B.
author_sort Aloy, Patrick
collection PubMed
description Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for interaction discovery, little attention has been paid to one of the best sources of data: complexes of known three-dimensional (3D) structure. Here we discuss how such complexes can be used to study and predict protein interactions and complexes, and to interrogate interaction networks proposed by methods such as two-hybrid screens or affinity purifications.
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spelling pubmed-24473742008-07-14 Understanding and Predicting Protein Assemblies With 3D Structures Aloy, Patrick Russell, Robert B. Comp Funct Genomics Research Article Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for interaction discovery, little attention has been paid to one of the best sources of data: complexes of known three-dimensional (3D) structure. Here we discuss how such complexes can be used to study and predict protein interactions and complexes, and to interrogate interaction networks proposed by methods such as two-hybrid screens or affinity purifications. Hindawi Publishing Corporation 2003-07 /pmc/articles/PMC2447374/ /pubmed/18629088 http://dx.doi.org/10.1002/cfg.310 Text en Copyright © 2003 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aloy, Patrick
Russell, Robert B.
Understanding and Predicting Protein Assemblies With 3D Structures
title Understanding and Predicting Protein Assemblies With 3D Structures
title_full Understanding and Predicting Protein Assemblies With 3D Structures
title_fullStr Understanding and Predicting Protein Assemblies With 3D Structures
title_full_unstemmed Understanding and Predicting Protein Assemblies With 3D Structures
title_short Understanding and Predicting Protein Assemblies With 3D Structures
title_sort understanding and predicting protein assemblies with 3d structures
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447374/
https://www.ncbi.nlm.nih.gov/pubmed/18629088
http://dx.doi.org/10.1002/cfg.310
work_keys_str_mv AT aloypatrick understandingandpredictingproteinassemblieswith3dstructures
AT russellrobertb understandingandpredictingproteinassemblieswith3dstructures

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