Global Analysis of Cell Type-Specific Gene Expression

The tissues and organs of multicellular eukaryotes are frequently observed to comprise complex three-dimensional interspersions of different cell types. It is a reasonable assumption that different global patterns of gene expression are found within these different cell types. This review outlines g...

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Detalles Bibliográficos
Autor principal: Galbraith, David W.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447418/
https://www.ncbi.nlm.nih.gov/pubmed/18629131
http://dx.doi.org/10.1002/cfg.281
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author Galbraith, David W.
author_facet Galbraith, David W.
author_sort Galbraith, David W.
collection PubMed
description The tissues and organs of multicellular eukaryotes are frequently observed to comprise complex three-dimensional interspersions of different cell types. It is a reasonable assumption that different global patterns of gene expression are found within these different cell types. This review outlines general experimental strategies designed to characterize these global gene expression patterns, based on a combination of methods of transgenic fluorescent protein (FP) expression and targeting, of flow cytometry and sorting and of high-throughput gene expression analysis.
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spelling pubmed-24474182008-07-14 Global Analysis of Cell Type-Specific Gene Expression Galbraith, David W. Comp Funct Genomics Research Article The tissues and organs of multicellular eukaryotes are frequently observed to comprise complex three-dimensional interspersions of different cell types. It is a reasonable assumption that different global patterns of gene expression are found within these different cell types. This review outlines general experimental strategies designed to characterize these global gene expression patterns, based on a combination of methods of transgenic fluorescent protein (FP) expression and targeting, of flow cytometry and sorting and of high-throughput gene expression analysis. Hindawi Publishing Corporation 2003-04 /pmc/articles/PMC2447418/ /pubmed/18629131 http://dx.doi.org/10.1002/cfg.281 Text en Copyright © 2003 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Galbraith, David W.
Global Analysis of Cell Type-Specific Gene Expression
title Global Analysis of Cell Type-Specific Gene Expression
title_full Global Analysis of Cell Type-Specific Gene Expression
title_fullStr Global Analysis of Cell Type-Specific Gene Expression
title_full_unstemmed Global Analysis of Cell Type-Specific Gene Expression
title_short Global Analysis of Cell Type-Specific Gene Expression
title_sort global analysis of cell type-specific gene expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447418/
https://www.ncbi.nlm.nih.gov/pubmed/18629131
http://dx.doi.org/10.1002/cfg.281
work_keys_str_mv AT galbraithdavidw globalanalysisofcelltypespecificgeneexpression

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