In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans

A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)(2)C(6)-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, inclu...

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Autores principales: Maicas, Sergi, Moreno, Inmaculada, Nieto, Almudena, Gómez, Micaela, Sentandreu, Rafael, Valentín, Eulogio
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447501/
https://www.ncbi.nlm.nih.gov/pubmed/18629206
http://dx.doi.org/10.1002/cfg.492
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author Maicas, Sergi
Moreno, Inmaculada
Nieto, Almudena
Gómez, Micaela
Sentandreu, Rafael
Valentín, Eulogio
author_facet Maicas, Sergi
Moreno, Inmaculada
Nieto, Almudena
Gómez, Micaela
Sentandreu, Rafael
Valentín, Eulogio
author_sort Maicas, Sergi
collection PubMed
description A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)(2)C(6)-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX(2)CysX(6)CysX(5-16)CysX(2)CysX(6-8)Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)(2)C(6) transcription factors have been found in the genome of C. albicans.
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spelling pubmed-24475012008-07-14 In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans Maicas, Sergi Moreno, Inmaculada Nieto, Almudena Gómez, Micaela Sentandreu, Rafael Valentín, Eulogio Comp Funct Genomics Research Article A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)(2)C(6)-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX(2)CysX(6)CysX(5-16)CysX(2)CysX(6-8)Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)(2)C(6) transcription factors have been found in the genome of C. albicans. Hindawi Publishing Corporation 2005 /pmc/articles/PMC2447501/ /pubmed/18629206 http://dx.doi.org/10.1002/cfg.492 Text en Copyright © 2005 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Maicas, Sergi
Moreno, Inmaculada
Nieto, Almudena
Gómez, Micaela
Sentandreu, Rafael
Valentín, Eulogio
In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans
title In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans
title_full In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans
title_fullStr In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans
title_full_unstemmed In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans
title_short In Silico Analysis for Transcription Factors With Zn(II)(2)C(6) Binuclear Cluster DNA-Binding Domains in Candida albicans
title_sort in silico analysis for transcription factors with zn(ii)(2)c(6) binuclear cluster dna-binding domains in candida albicans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447501/
https://www.ncbi.nlm.nih.gov/pubmed/18629206
http://dx.doi.org/10.1002/cfg.492
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