Making the jump: new insights into the mechanism of trans-translation

The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the riboso...

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Detalles Bibliográficos
Autores principales: Wower, Jacek, Wower, Iwona K, Zwieb, Christian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447533/
https://www.ncbi.nlm.nih.gov/pubmed/18598387
http://dx.doi.org/10.1186/jbiol78
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author Wower, Jacek
Wower, Iwona K
Zwieb, Christian
author_facet Wower, Jacek
Wower, Iwona K
Zwieb, Christian
author_sort Wower, Jacek
collection PubMed
description The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.
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spelling pubmed-24475332008-07-10 Making the jump: new insights into the mechanism of trans-translation Wower, Jacek Wower, Iwona K Zwieb, Christian J Biol Minireview The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat. BioMed Central 2008 2008-06-30 /pmc/articles/PMC2447533/ /pubmed/18598387 http://dx.doi.org/10.1186/jbiol78 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Minireview
Wower, Jacek
Wower, Iwona K
Zwieb, Christian
Making the jump: new insights into the mechanism of trans-translation
title Making the jump: new insights into the mechanism of trans-translation
title_full Making the jump: new insights into the mechanism of trans-translation
title_fullStr Making the jump: new insights into the mechanism of trans-translation
title_full_unstemmed Making the jump: new insights into the mechanism of trans-translation
title_short Making the jump: new insights into the mechanism of trans-translation
title_sort making the jump: new insights into the mechanism of trans-translation
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447533/
https://www.ncbi.nlm.nih.gov/pubmed/18598387
http://dx.doi.org/10.1186/jbiol78
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AT zwiebchristian makingthejumpnewinsightsintothemechanismoftranstranslation

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