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Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to p...

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Detalles Bibliográficos
Autores principales:	Bonetti, Paola, Davoli, Teresa, Sironi, Cristina, Amati, Bruno, Pelicci, Pier Giuseppe, Colombo, Emanuela
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447890/ https://www.ncbi.nlm.nih.gov/pubmed/18625840 http://dx.doi.org/10.1083/jcb.200711040

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