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Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

Deadenylation is the major step triggering mammalian mRNA decay. One consequence of deadenylation is the formation of nontranslatable messenger RNA (mRNA) protein complexes (messenger ribonucleoproteins [mRNPs]). Nontranslatable mRNPs may accumulate in P-bodies, which contain factors involved in tra...

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Detalles Bibliográficos
Autores principales:	Zheng, Dinghai, Ezzeddine, Nader, Chen, Chyi-Ying A., Zhu, Wenmiao, He, Xiangwei, Shyu, Ann-Bin
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447901/ https://www.ncbi.nlm.nih.gov/pubmed/18625844 http://dx.doi.org/10.1083/jcb.200801196

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