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TWEAKing death
Smac mimetics (inhibitor of apoptosis [IAP] antagonists) are synthetic reagents that kill susceptible tumor cells by inducing degradation of cellular IAP (cIAP) 1 and cIAP2, nuclear factor κB activation, tumor necrosis factor (TNF) α production, TNF receptor 1 occupancy, and caspase-8 activation. In...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447904/ https://www.ncbi.nlm.nih.gov/pubmed/18606854 http://dx.doi.org/10.1083/jcb.200806036 |