Improved patient and graft survival using cyclosporin A in cadaver renal transplantation

In two consecutive prospective randomised trials cyclosporin A has been compared with conventional immunosuppressive therapy (azathioprine and steroids) and with cyclosporin combined with steroids. The present report is a 4 year review and includes 165 patients. Cyclosporin A alone had a significant...

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Detalles Bibliográficos
Autor principal: Johnson, R W G
Formato: Texto
Lenguaje:English
Publicado: 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447967/
https://www.ncbi.nlm.nih.gov/pubmed/3909587
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author Johnson, R W G
author_facet Johnson, R W G
author_sort Johnson, R W G
collection PubMed
description In two consecutive prospective randomised trials cyclosporin A has been compared with conventional immunosuppressive therapy (azathioprine and steroids) and with cyclosporin combined with steroids. The present report is a 4 year review and includes 165 patients. Cyclosporin A alone had a significant advantage over conventional therapy at both 1 and 3 years (p = 0.02) for both patient and graft survival. No significant difference was seen when cyclosporin was combined with steroids. Nephrotoxicity was the most troublesome side-effect of cyclosporin A — but this resolved spontaneously on withdrawal of the drug.
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spelling pubmed-24479672008-07-10 Improved patient and graft survival using cyclosporin A in cadaver renal transplantation Johnson, R W G Ulster Med J Articles In two consecutive prospective randomised trials cyclosporin A has been compared with conventional immunosuppressive therapy (azathioprine and steroids) and with cyclosporin combined with steroids. The present report is a 4 year review and includes 165 patients. Cyclosporin A alone had a significant advantage over conventional therapy at both 1 and 3 years (p = 0.02) for both patient and graft survival. No significant difference was seen when cyclosporin was combined with steroids. Nephrotoxicity was the most troublesome side-effect of cyclosporin A — but this resolved spontaneously on withdrawal of the drug. 1985-08 /pmc/articles/PMC2447967/ /pubmed/3909587 Text en
spellingShingle Articles
Johnson, R W G
Improved patient and graft survival using cyclosporin A in cadaver renal transplantation
title Improved patient and graft survival using cyclosporin A in cadaver renal transplantation
title_full Improved patient and graft survival using cyclosporin A in cadaver renal transplantation
title_fullStr Improved patient and graft survival using cyclosporin A in cadaver renal transplantation
title_full_unstemmed Improved patient and graft survival using cyclosporin A in cadaver renal transplantation
title_short Improved patient and graft survival using cyclosporin A in cadaver renal transplantation
title_sort improved patient and graft survival using cyclosporin a in cadaver renal transplantation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447967/
https://www.ncbi.nlm.nih.gov/pubmed/3909587
work_keys_str_mv AT johnsonrwg improvedpatientandgraftsurvivalusingcyclosporinaincadaverrenaltransplantation

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