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Gliadin antibody detection in gluten enteropathy

Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two...

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Detalles Bibliográficos
Autores principales: Watson, R G P, McMillan, S A, Dolan, Clare, O'Farrelly, Cliona, Cuthbert, R J G, Haire, Margaret, Weir, D G, Porter, K G
Formato: Texto
Lenguaje:English
Publicado: 1986
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448356/
https://www.ncbi.nlm.nih.gov/pubmed/3811015
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author Watson, R G P
McMillan, S A
Dolan, Clare
O'Farrelly, Cliona
Cuthbert, R J G
Haire, Margaret
Weir, D G
Porter, K G
author_facet Watson, R G P
McMillan, S A
Dolan, Clare
O'Farrelly, Cliona
Cuthbert, R J G
Haire, Margaret
Weir, D G
Porter, K G
author_sort Watson, R G P
collection PubMed
description Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two different techniques for assaying these antibodies — an indirect immunofluorescent method and an enzyme-linked immunosorbent assay (ELISA). Antibodies were assayed in the sera of 102 patients in whom jejunal biopsies were also obtained. The specificity of both tests was greater than 95%, and the correlation between the presence of antibody and histology was significant (p < 0.005), though the sensitivity of each test was less than 70%.
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spelling pubmed-24483562008-07-10 Gliadin antibody detection in gluten enteropathy Watson, R G P McMillan, S A Dolan, Clare O'Farrelly, Cliona Cuthbert, R J G Haire, Margaret Weir, D G Porter, K G Ulster Med J Articles Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two different techniques for assaying these antibodies — an indirect immunofluorescent method and an enzyme-linked immunosorbent assay (ELISA). Antibodies were assayed in the sera of 102 patients in whom jejunal biopsies were also obtained. The specificity of both tests was greater than 95%, and the correlation between the presence of antibody and histology was significant (p < 0.005), though the sensitivity of each test was less than 70%. 1986-10 /pmc/articles/PMC2448356/ /pubmed/3811015 Text en
spellingShingle Articles
Watson, R G P
McMillan, S A
Dolan, Clare
O'Farrelly, Cliona
Cuthbert, R J G
Haire, Margaret
Weir, D G
Porter, K G
Gliadin antibody detection in gluten enteropathy
title Gliadin antibody detection in gluten enteropathy
title_full Gliadin antibody detection in gluten enteropathy
title_fullStr Gliadin antibody detection in gluten enteropathy
title_full_unstemmed Gliadin antibody detection in gluten enteropathy
title_short Gliadin antibody detection in gluten enteropathy
title_sort gliadin antibody detection in gluten enteropathy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448356/
https://www.ncbi.nlm.nih.gov/pubmed/3811015
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