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Gliadin antibody detection in gluten enteropathy
Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1986
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448356/ https://www.ncbi.nlm.nih.gov/pubmed/3811015 |
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author | Watson, R G P McMillan, S A Dolan, Clare O'Farrelly, Cliona Cuthbert, R J G Haire, Margaret Weir, D G Porter, K G |
author_facet | Watson, R G P McMillan, S A Dolan, Clare O'Farrelly, Cliona Cuthbert, R J G Haire, Margaret Weir, D G Porter, K G |
author_sort | Watson, R G P |
collection | PubMed |
description | Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two different techniques for assaying these antibodies — an indirect immunofluorescent method and an enzyme-linked immunosorbent assay (ELISA). Antibodies were assayed in the sera of 102 patients in whom jejunal biopsies were also obtained. The specificity of both tests was greater than 95%, and the correlation between the presence of antibody and histology was significant (p < 0.005), though the sensitivity of each test was less than 70%. |
format | Text |
id | pubmed-2448356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1986 |
record_format | MEDLINE/PubMed |
spelling | pubmed-24483562008-07-10 Gliadin antibody detection in gluten enteropathy Watson, R G P McMillan, S A Dolan, Clare O'Farrelly, Cliona Cuthbert, R J G Haire, Margaret Weir, D G Porter, K G Ulster Med J Articles Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two different techniques for assaying these antibodies — an indirect immunofluorescent method and an enzyme-linked immunosorbent assay (ELISA). Antibodies were assayed in the sera of 102 patients in whom jejunal biopsies were also obtained. The specificity of both tests was greater than 95%, and the correlation between the presence of antibody and histology was significant (p < 0.005), though the sensitivity of each test was less than 70%. 1986-10 /pmc/articles/PMC2448356/ /pubmed/3811015 Text en |
spellingShingle | Articles Watson, R G P McMillan, S A Dolan, Clare O'Farrelly, Cliona Cuthbert, R J G Haire, Margaret Weir, D G Porter, K G Gliadin antibody detection in gluten enteropathy |
title | Gliadin antibody detection in gluten enteropathy |
title_full | Gliadin antibody detection in gluten enteropathy |
title_fullStr | Gliadin antibody detection in gluten enteropathy |
title_full_unstemmed | Gliadin antibody detection in gluten enteropathy |
title_short | Gliadin antibody detection in gluten enteropathy |
title_sort | gliadin antibody detection in gluten enteropathy |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448356/ https://www.ncbi.nlm.nih.gov/pubmed/3811015 |
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