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InterPro (The Integrated Resource of Protein Domains and Functional Sites)
The family and motif databases, PROSITE, PRINTS, Pfam and ProDom, have been integrated into a powerful resource for protein secondary annotation. As of June 2000, InterPro had processed 384 572 proteins in SWISS-PROT and TrEMBL. Because the contributing databases have different clustering principles...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448387/ https://www.ncbi.nlm.nih.gov/pubmed/11119311 http://dx.doi.org/10.1002/1097-0061(200012)17:4<327::AID-YEA45>3.0.CO;2-K |
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author | Southan, Christopher |
author_facet | Southan, Christopher |
author_sort | Southan, Christopher |
collection | PubMed |
description | The family and motif databases, PROSITE, PRINTS, Pfam and ProDom, have been integrated into a powerful resource for protein secondary annotation. As of June 2000, InterPro had processed 384 572 proteins in SWISS-PROT and TrEMBL. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments compliment each other for grouping protein families and delineating domains. The graphic displays of all matches above the scoring thresholds enables judgements to be made on the concordances or differences between the assignments. The website links can be used to analyse novel sequences and for queries across the proteomes of 32 organisms, including the partial human set, by domain and/or protein family. An analysis of selected HtrA/DegQ proteases demonstrates the utility of this website for detailed comparative genomics. Further information on the project can be found at the European Bioinformatics Institute at http://www.ebi.ac.uk/interpro/. |
format | Text |
id | pubmed-2448387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24483872008-07-14 InterPro (The Integrated Resource of Protein Domains and Functional Sites) Southan, Christopher Yeast Research Article The family and motif databases, PROSITE, PRINTS, Pfam and ProDom, have been integrated into a powerful resource for protein secondary annotation. As of June 2000, InterPro had processed 384 572 proteins in SWISS-PROT and TrEMBL. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments compliment each other for grouping protein families and delineating domains. The graphic displays of all matches above the scoring thresholds enables judgements to be made on the concordances or differences between the assignments. The website links can be used to analyse novel sequences and for queries across the proteomes of 32 organisms, including the partial human set, by domain and/or protein family. An analysis of selected HtrA/DegQ proteases demonstrates the utility of this website for detailed comparative genomics. Further information on the project can be found at the European Bioinformatics Institute at http://www.ebi.ac.uk/interpro/. Hindawi Publishing Corporation 2000 /pmc/articles/PMC2448387/ /pubmed/11119311 http://dx.doi.org/10.1002/1097-0061(200012)17:4<327::AID-YEA45>3.0.CO;2-K Text en Copyright © 2000 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Southan, Christopher InterPro (The Integrated Resource of Protein Domains and Functional Sites) |
title | InterPro (The Integrated Resource of Protein Domains and Functional Sites) |
title_full | InterPro (The Integrated Resource of Protein Domains and Functional Sites) |
title_fullStr | InterPro (The Integrated Resource of Protein Domains and Functional Sites) |
title_full_unstemmed | InterPro (The Integrated Resource of Protein Domains and Functional Sites) |
title_short | InterPro (The Integrated Resource of Protein Domains and Functional Sites) |
title_sort | interpro (the integrated resource of protein domains and functional sites) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448387/ https://www.ncbi.nlm.nih.gov/pubmed/11119311 http://dx.doi.org/10.1002/1097-0061(200012)17:4<327::AID-YEA45>3.0.CO;2-K |
work_keys_str_mv | AT southanchristopher interprotheintegratedresourceofproteindomainsandfunctionalsites |