Harvesting the Mouse Genome

The sequencing of the black 6 mouse (strain C57Bl/6) has reached an important juncture. The BAC fingerprint map is almost complete, the BACs have been endsequenced and a seven-fold coverage whole-genome shotgun has been assembled. Now the BAC-by-BAC sequencing phase is under way and in-depth compara...

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Detalles Bibliográficos
Autor principal: Botcherby, Marc
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448424/
https://www.ncbi.nlm.nih.gov/pubmed/18629261
http://dx.doi.org/10.1002/cfg.198
Descripción
Sumario:The sequencing of the black 6 mouse (strain C57Bl/6) has reached an important juncture. The BAC fingerprint map is almost complete, the BACs have been endsequenced and a seven-fold coverage whole-genome shotgun has been assembled. Now the BAC-by-BAC sequencing phase is under way and in-depth comparative analysis can be carried out on regions that have been the subject of targeted sequencing. This paper reviews the progress so far and looks forward to the promises of finished sequence.

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