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Large-scale gene-expression studies and the challenge of multiple sclerosis

In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different sta...

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Detalles Bibliográficos
Autores principales: Baranzini, Sergio E, Hauser, Stephen L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC244911/
https://www.ncbi.nlm.nih.gov/pubmed/12372148
http://dx.doi.org/10.1186/gb-2002-3-10-reviews1027
Descripción
Sumario:In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.