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Large-scale gene-expression studies and the challenge of multiple sclerosis

In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different sta...

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Detalles Bibliográficos
Autores principales: Baranzini, Sergio E, Hauser, Stephen L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC244911/
https://www.ncbi.nlm.nih.gov/pubmed/12372148
http://dx.doi.org/10.1186/gb-2002-3-10-reviews1027
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author Baranzini, Sergio E
Hauser, Stephen L
author_facet Baranzini, Sergio E
Hauser, Stephen L
author_sort Baranzini, Sergio E
collection PubMed
description In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.
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spelling pubmed-2449112003-11-06 Large-scale gene-expression studies and the challenge of multiple sclerosis Baranzini, Sergio E Hauser, Stephen L Genome Biol Minireview In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy. BioMed Central 2002 2002-09-16 /pmc/articles/PMC244911/ /pubmed/12372148 http://dx.doi.org/10.1186/gb-2002-3-10-reviews1027 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Minireview
Baranzini, Sergio E
Hauser, Stephen L
Large-scale gene-expression studies and the challenge of multiple sclerosis
title Large-scale gene-expression studies and the challenge of multiple sclerosis
title_full Large-scale gene-expression studies and the challenge of multiple sclerosis
title_fullStr Large-scale gene-expression studies and the challenge of multiple sclerosis
title_full_unstemmed Large-scale gene-expression studies and the challenge of multiple sclerosis
title_short Large-scale gene-expression studies and the challenge of multiple sclerosis
title_sort large-scale gene-expression studies and the challenge of multiple sclerosis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC244911/
https://www.ncbi.nlm.nih.gov/pubmed/12372148
http://dx.doi.org/10.1186/gb-2002-3-10-reviews1027
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