Cargando…

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study

INTRODUCTION: High-mobility group box chromosomal protein 1 (HMGB1) has recently been identified as an endogenous mediator of arthritis. TNF and IL-1β, pivotal cytokines in arthritis pathogenesis, both have the ability to induce the release of HMGB1 from myeloid and dendritic cells. It was, therefor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sundberg, Erik, Grundtman, Cecilia, af Klint, Erik, Lindberg, Johan, Ernestam, Sofia, Ulfgren, Ann-Kristin, Harris, Helena Erlandsson, Andersson, Ulf
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2452983/ https://www.ncbi.nlm.nih.gov/pubmed/18346273 http://dx.doi.org/10.1186/ar2387

Ejemplares similares

Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor
por: Ernestam, Sofia, et al.
Publicado: (2006)

Intra-articular steroid treatment reduces synovial HMGB1 but not IL-1 expression in chronic arthritis
por: Grundtman, C, et al.
Publicado: (2004)

Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology
por: Lindberg, Johan, et al.
Publicado: (2006)

Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients
por: Lindberg, Johan, et al.
Publicado: (2006)

Anti-tumour necrosis factor therapy modulates the OPG/OPGL system in rheumatoid arthritis synovium
por: Catrina, AI, et al.
Publicado: (2004)

Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis
por: Makrygiannakis, Dimitrios, et al.
Publicado: (2008)

HMGB1, a new proinflammatory molecule of interest in polymyositis and dermatomyositis patients
por: Grundtman, C, et al.
Publicado: (2003)

Patterns of gene expression in rheumatoid arthritis synovial tissue: inter-patient variability greater then intra-patient variability in a small study
por: Lindberg, J, et al.
Publicado: (2005)

Distinct patterns of RANKL/osteoprotegerin system modulation through anti-tumour necrosis factor and corticosteroid therapy in rheumatoid arthritis synovium
por: Catrina, AI, et al.
Publicado: (2005)

HMGB1 is a potent proinflammatory mediator expressed abundantly in chronic synovitis
por: Andersson, UG, et al.
Publicado: (2002)

Effects of anti-rheumatic treatments on the prostaglandin E(2 )biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis
por: Korotkova, M, et al.
Publicado: (2005)

Therapy with soluble TNF receptor (etanercept) induces apoptosis in rheumatoid arthritis (RA) synovium
por: Catrina, AI, et al.
Publicado: (2003)

Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
por: Makrygiannakis, Dimitrios, et al.
Publicado: (2012)

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis
por: Palmblad, Karin, et al.
Publicado: (2007)

High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis
por: Magnusson, Sofia E, et al.
Publicado: (2007)

Therapeutic administration of etoposide coincides with reduced systemic HMGB1 levels in macrophage activation syndrome
por: Palmblad, Karin, et al.
Publicado: (2021)

Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate
por: Revu, Shankar, et al.
Publicado: (2013)

Cytokine active disulfide-HMGB1 increased during severe macrophage activation syndrome
por: Schierbeck, Hanna, et al.
Publicado: (2014)

Heterogeneity in cytokine profile after intra-articular steroid treatment
por: AfKlint, ENG, et al.
Publicado: (2002)

Expression of concern to: High systematic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome
por: Palmblad, Karin, et al.
Publicado: (2020)

Retraction Note to: High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome
por: Palmblad, Karin, et al.
Publicado: (2020)

Skewed distribution of proinflammatory CD4(+)CD28(null )T cells in rheumatoid arthritis
por: Fasth, Andreas ER, et al.
Publicado: (2007)

Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
por: Korotkova, M, et al.
Publicado: (2004)

A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients
por: Nerviani, Alessandra, et al.
Publicado: (2020)

Evaluation of arthroscopy and macroscopic scoring
por: af Klint, Erik, et al.
Publicado: (2009)

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
por: Pisetsky, David S, et al.
Publicado: (2008)

Differential gene expression and protein expression levels of MMP and TIMP molecules in response to glucocorticoid treatment in arthritic patients
por: Andersson, T, et al.
Publicado: (2004)

Chemokine blockade in patients with rheumatoid arthritis: reduction of synovial inflammation
por: Haringman, JJ, et al.
Publicado: (2002)

Metabolic signature and proteasome activity controls synovial migration of CDC42(hi) CD14(+) cells in rheumatoid arthritis
por: Malmhäll-Bah, Eric, et al.
Publicado: (2023)

HMGB1–LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype
por: Qin, Y, et al.
Publicado: (2014)

AKT regulates TNF-alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts
por: Mountz, JD, et al.
Publicado: (2001)

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
por: Connor, Alison M, et al.
Publicado: (2012)

Rheumatoid arthritis chondrocytes produce increased levels of pro-inflammatory proteins
por: Önnheim, Karin, et al.
Publicado: (2022)

Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats
por: Terrando, Niccolò, et al.
Publicado: (2016)

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
por: Gheorghe, Karina Roxana, et al.
Publicado: (2009)

Redox modifications of cysteine residues regulate the cytokine activity of HMGB1
por: Yang, Huan, et al.
Publicado: (2021)

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
por: Östberg, Therese, et al.
Publicado: (2008)

Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis
por: Kim, Hye Young, et al.
Publicado: (2014)

Targeting Inflammation Driven by HMGB1
por: Yang, Huan, et al.
Publicado: (2020)

Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
por: Müller-Ladner, Ulf, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ucq2vv81km1odrn7ek92c0j5o1