Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma

Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib. By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were i...

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Detalles Bibliográficos
Autores principales: Dahse, R, Kosmehl, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453031/
https://www.ncbi.nlm.nih.gov/pubmed/18542074
http://dx.doi.org/10.1038/sj.bjc.6604430
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author Dahse, R
Kosmehl, H
author_facet Dahse, R
Kosmehl, H
author_sort Dahse, R
collection PubMed
description Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib. By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland.
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spelling pubmed-24530312009-09-11 Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma Dahse, R Kosmehl, H Br J Cancer Short Communication Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib. By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland. Nature Publishing Group 2008-07-08 2008-06-10 /pmc/articles/PMC2453031/ /pubmed/18542074 http://dx.doi.org/10.1038/sj.bjc.6604430 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Dahse, R
Kosmehl, H
Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
title Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
title_full Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
title_fullStr Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
title_full_unstemmed Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
title_short Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
title_sort detection of drug-sensitizing egfr exon 19 deletion mutations in salivary gland carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453031/
https://www.ncbi.nlm.nih.gov/pubmed/18542074
http://dx.doi.org/10.1038/sj.bjc.6604430
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