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α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients
Serum chromogranin A is the most useful general and prognostic tumour marker available for neuroendocrine tumour (NET) patients. The role of other tumour markers is less clear. In order to determine the diagnostic and prognostic value of serum α-fetoprotein (AFP) and human chorionic gonadotrophin-β...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453040/ https://www.ncbi.nlm.nih.gov/pubmed/18577995 http://dx.doi.org/10.1038/sj.bjc.6604428 |
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author | Shah, T Srirajaskanthan, R Bhogal, M Toubanakis, C Meyer, T Noonan, A Witney-Smith, C Amin, T Bhogal, P Sivathasan, N Warner, B Hochhauser, D Caplin, M E |
author_facet | Shah, T Srirajaskanthan, R Bhogal, M Toubanakis, C Meyer, T Noonan, A Witney-Smith, C Amin, T Bhogal, P Sivathasan, N Warner, B Hochhauser, D Caplin, M E |
author_sort | Shah, T |
collection | PubMed |
description | Serum chromogranin A is the most useful general and prognostic tumour marker available for neuroendocrine tumour (NET) patients. The role of other tumour markers is less clear. In order to determine the diagnostic and prognostic value of serum α-fetoprotein (AFP) and human chorionic gonadotrophin-β (hCGβ) in NETs, a database containing biochemical, histological, and survival data on 360 NET patients was constructed. This data was statistically assessed, using Statistical Package for the Social Sciences, to determine the utility of commonly measured tumour markers with particular emphasis on AFP and hCGβ. α-Fetoprotein and hCGβ were raised in 9.5 and 12.3% of patients respectively and jointly raised in 9.1% of patients in whom it was measured. α-Fetoprotein levels associated strongly and positively with tumour grade, serum CgA and hCGβ levels, and worse survival. Human chorionic gonadotrophin-β levels also associated strongly and positively with serum CgA and AFP levels, and worsening survival. α-Fetoprotein and hCGβ are elevated in high-grade NETs, with a rapidly progressive course and poorer survival. They also correlate with chromogranin-A, which is known to be a marker of tumour burden and to have prognostic value. Thus AFP and hCGβ are clinically important in NETs and when elevated are poor prognostic markers. |
format | Text |
id | pubmed-2453040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-24530402009-09-11 α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients Shah, T Srirajaskanthan, R Bhogal, M Toubanakis, C Meyer, T Noonan, A Witney-Smith, C Amin, T Bhogal, P Sivathasan, N Warner, B Hochhauser, D Caplin, M E Br J Cancer Clinical Study Serum chromogranin A is the most useful general and prognostic tumour marker available for neuroendocrine tumour (NET) patients. The role of other tumour markers is less clear. In order to determine the diagnostic and prognostic value of serum α-fetoprotein (AFP) and human chorionic gonadotrophin-β (hCGβ) in NETs, a database containing biochemical, histological, and survival data on 360 NET patients was constructed. This data was statistically assessed, using Statistical Package for the Social Sciences, to determine the utility of commonly measured tumour markers with particular emphasis on AFP and hCGβ. α-Fetoprotein and hCGβ were raised in 9.5 and 12.3% of patients respectively and jointly raised in 9.1% of patients in whom it was measured. α-Fetoprotein levels associated strongly and positively with tumour grade, serum CgA and hCGβ levels, and worse survival. Human chorionic gonadotrophin-β levels also associated strongly and positively with serum CgA and AFP levels, and worsening survival. α-Fetoprotein and hCGβ are elevated in high-grade NETs, with a rapidly progressive course and poorer survival. They also correlate with chromogranin-A, which is known to be a marker of tumour burden and to have prognostic value. Thus AFP and hCGβ are clinically important in NETs and when elevated are poor prognostic markers. Nature Publishing Group 2008-07-08 2008-06-24 /pmc/articles/PMC2453040/ /pubmed/18577995 http://dx.doi.org/10.1038/sj.bjc.6604428 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Study Shah, T Srirajaskanthan, R Bhogal, M Toubanakis, C Meyer, T Noonan, A Witney-Smith, C Amin, T Bhogal, P Sivathasan, N Warner, B Hochhauser, D Caplin, M E α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
title | α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
title_full | α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
title_fullStr | α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
title_full_unstemmed | α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
title_short | α-Fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
title_sort | α-fetoprotein and human chorionic gonadotrophin-β as prognostic markers in neuroendocrine tumour patients |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453040/ https://www.ncbi.nlm.nih.gov/pubmed/18577995 http://dx.doi.org/10.1038/sj.bjc.6604428 |
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