The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of TBK1. TBK1 and DDX3X acted synergistically in their ability to stimulate the IFN promoter, whereas RNAi-...

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Detalles Bibliográficos
Autores principales: Soulat, Didier, Bürckstümmer, Tilmann, Westermayer, Sandra, Goncalves, Adriana, Bauch, Angela, Stefanovic, Adrijana, Hantschel, Oliver, Bennett, Keiryn L, Decker, Thomas, Superti-Furga, Giulio
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453059/
https://www.ncbi.nlm.nih.gov/pubmed/18583960
http://dx.doi.org/10.1038/emboj.2008.126

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