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Purification and characterization of recombinant human renin for X-ray crystallization studies

BACKGROUND: The renin-angiotensin-aldosterone system (RAS) cascade is a major target for the clinical management of hypertension. Although inhibitors of various components of this cascade have been developed successfully, development of renin inhibitors has proven to be problematic. The development...

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Detalles Bibliográficos
Autores principales: Wu, Zhongren, Cappiello, Maria G, Scott, Boyd B, Bukhtiyarov, Yuri, McGeehan, Gerard M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453115/
https://www.ncbi.nlm.nih.gov/pubmed/18582379
http://dx.doi.org/10.1186/1471-2091-9-19