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Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT)
BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453123/ https://www.ncbi.nlm.nih.gov/pubmed/18578865 http://dx.doi.org/10.1186/1471-244X-8-48 |
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author | Bækken, Petter M Skorpen, Frank Stordal, Eystein Zwart, John-Anker Hagen, Knut |
author_facet | Bækken, Petter M Skorpen, Frank Stordal, Eystein Zwart, John-Anker Hagen, Knut |
author_sort | Bækken, Petter M |
collection | PubMed |
description | BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS) in the general adult population. METHODS: In the Nord-Trøndelag Health Study (HUNT) the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (≥ 8 and ≥ 11) were used to identify cases with anxiety (HADS-A) and depression (HADS-D), whereas controls had HADS-A <8 and HADS-D <8. RESULTS: The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cut-off score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11) was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76). CONCLUSION: In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding. |
format | Text |
id | pubmed-2453123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24531232008-07-11 Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) Bækken, Petter M Skorpen, Frank Stordal, Eystein Zwart, John-Anker Hagen, Knut BMC Psychiatry Research Article BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS) in the general adult population. METHODS: In the Nord-Trøndelag Health Study (HUNT) the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (≥ 8 and ≥ 11) were used to identify cases with anxiety (HADS-A) and depression (HADS-D), whereas controls had HADS-A <8 and HADS-D <8. RESULTS: The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cut-off score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11) was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76). CONCLUSION: In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding. BioMed Central 2008-06-25 /pmc/articles/PMC2453123/ /pubmed/18578865 http://dx.doi.org/10.1186/1471-244X-8-48 Text en Copyright © 2008 Bækken et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bækken, Petter M Skorpen, Frank Stordal, Eystein Zwart, John-Anker Hagen, Knut Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) |
title | Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) |
title_full | Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) |
title_fullStr | Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) |
title_full_unstemmed | Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) |
title_short | Depression and anxiety in relation to catechol-O-methyltransferase Val(158)Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) |
title_sort | depression and anxiety in relation to catechol-o-methyltransferase val(158)met genotype in the general population: the nord-trøndelag health study (hunt) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453123/ https://www.ncbi.nlm.nih.gov/pubmed/18578865 http://dx.doi.org/10.1186/1471-244X-8-48 |
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