CD4-Specific Designed Ankyrin Repeat Proteins Are Novel Potent HIV Entry Inhibitors with Unique Characteristics

Here, we describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin) technology. DARPin proteins specific for human CD4 were selected from a DARPin DNA library using ribosome display. Selected pool members interacted specifical...

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Detalles Bibliográficos
Autores principales: Schweizer, Andreas, Rusert, Peter, Berlinger, Livia, Ruprecht, Claudia R., Mann, Axel, Corthésy, Stéphanie, Turville, Stuart G., Aravantinou, Meropi, Fischer, Marek, Robbiani, Melissa, Amstutz, Patrick, Trkola, Alexandra
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453315/
https://www.ncbi.nlm.nih.gov/pubmed/18654624
http://dx.doi.org/10.1371/journal.ppat.1000109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453315/
https://www.ncbi.nlm.nih.gov/pubmed/18654624
http://dx.doi.org/10.1371/journal.ppat.1000109

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