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High Protein Binding and Cidal Activity against Penicillin-Resistant S. pneumoniae: A Cefditoren In Vitro Pharmacodynamic Simulation

BACKGROUND: Although protein binding is a reversible phenomenon, it is assumed that antibacterial activity is exclusively exerted by the free (unbound) fraction of antibiotics. METHODOLOGY/PRINCIPAL FINDINGS: Activity of cefditoren, a highly protein bound 3(rd) generation cephalosporin, over 24h aft...

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Detalles Bibliográficos
Autores principales:	Sevillano, David, Aguilar, Lorenzo, Alou, Luis, Giménez, María-José, González, Natalia, Torrico, Martha, Cafini, Fabio, Fenoll, Asunción, Coronel, Pilar, Prieto, José
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453320/ https://www.ncbi.nlm.nih.gov/pubmed/18648650 http://dx.doi.org/10.1371/journal.pone.0002717

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