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Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

OBJECTIVE—Weak major histocompatibility complex (MHC) binding of self-peptides has been proposed as a mechanism that may contribute to autoimmunity by allowing for escape of autoreactive T-cells from the thymus. We examined the relationship between the MHC-binding characteristics of a β-cell antigen...

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Detalles Bibliográficos
Autores principales:	Levisetti, Matteo G., Lewis, Danna M., Suri, Anish, Unanue, Emil R.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453633/ https://www.ncbi.nlm.nih.gov/pubmed/18398138 http://dx.doi.org/10.2337/db08-0068

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