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Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.

OBJECTIVE—Although metabolic syndrome is related to an increased risk of coronary heart disease (CHD) events, individuals with metabolic syndrome encompass a wide range of CHD risk levels. This study describes the distribution of 10-year CHD risk among U.S. adults with metabolic syndrome. RESEARCH D...

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Detalles Bibliográficos
Autores principales: Hoang, Khiet C., Ghandehari, Heli, Lopez, Victor A., Barboza, Michael G., Wong, Nathan D.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453646/
https://www.ncbi.nlm.nih.gov/pubmed/18375418
http://dx.doi.org/10.2337/dc07-2087
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author Hoang, Khiet C.
Ghandehari, Heli
Lopez, Victor A.
Barboza, Michael G.
Wong, Nathan D.
author_facet Hoang, Khiet C.
Ghandehari, Heli
Lopez, Victor A.
Barboza, Michael G.
Wong, Nathan D.
author_sort Hoang, Khiet C.
collection PubMed
description OBJECTIVE—Although metabolic syndrome is related to an increased risk of coronary heart disease (CHD) events, individuals with metabolic syndrome encompass a wide range of CHD risk levels. This study describes the distribution of 10-year CHD risk among U.S. adults with metabolic syndrome. RESEARCH DESIGN AND METHODS—Metabolic syndrome was defined by the modified National Cholesterol Education Program (NCEP)/Third Adult Treatment Panel (ATP III) definition among 4,293 U.S. adults aged 20–79 years in the National Health and Nutrition Examination Survey 2003–2004. Low-, moderate-, moderately high–, and high-risk statuses were defined as <6, 6 to <10, 10–20, and >20% probability of CHD in 10 years (based on NCEP/ATP III Framingham risk score algorithms), respectively; those with diabetes or preexisting cardiovascular disease were assigned to high-risk status. RESULTS—The weighted prevalence of metabolic syndrome by NCEP criteria in our study was 29.0% overall (30.0% in men and 27.9% in women, P = 0.28): 38.5% (30.7% men and 46.9% women) were classified as low risk, 8.5% (7.9% men and 9.1% women) were classified as moderate risk, 15.8% (23.4% men and 7.6% women) were classified as moderately high risk, and 37.3% (38.0% men and 36.5% women) were classified as high risk. The proportion at high risk increased with age but was similar among Hispanics, non-Hispanic whites, and non-Hispanic blacks. CONCLUSIONS—Although many subjects with metabolic syndrome have a low calculated risk for CHD, about half have a moderately high or high risk, reinforcing the need for global risk assessment in individuals with metabolic syndrome to appropriately target intensity of treatment for underlying CHD risk factors.
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spelling pubmed-24536462009-07-01 Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S. Hoang, Khiet C. Ghandehari, Heli Lopez, Victor A. Barboza, Michael G. Wong, Nathan D. Diabetes Care Cardiovascular and Metabolic Risk OBJECTIVE—Although metabolic syndrome is related to an increased risk of coronary heart disease (CHD) events, individuals with metabolic syndrome encompass a wide range of CHD risk levels. This study describes the distribution of 10-year CHD risk among U.S. adults with metabolic syndrome. RESEARCH DESIGN AND METHODS—Metabolic syndrome was defined by the modified National Cholesterol Education Program (NCEP)/Third Adult Treatment Panel (ATP III) definition among 4,293 U.S. adults aged 20–79 years in the National Health and Nutrition Examination Survey 2003–2004. Low-, moderate-, moderately high–, and high-risk statuses were defined as <6, 6 to <10, 10–20, and >20% probability of CHD in 10 years (based on NCEP/ATP III Framingham risk score algorithms), respectively; those with diabetes or preexisting cardiovascular disease were assigned to high-risk status. RESULTS—The weighted prevalence of metabolic syndrome by NCEP criteria in our study was 29.0% overall (30.0% in men and 27.9% in women, P = 0.28): 38.5% (30.7% men and 46.9% women) were classified as low risk, 8.5% (7.9% men and 9.1% women) were classified as moderate risk, 15.8% (23.4% men and 7.6% women) were classified as moderately high risk, and 37.3% (38.0% men and 36.5% women) were classified as high risk. The proportion at high risk increased with age but was similar among Hispanics, non-Hispanic whites, and non-Hispanic blacks. CONCLUSIONS—Although many subjects with metabolic syndrome have a low calculated risk for CHD, about half have a moderately high or high risk, reinforcing the need for global risk assessment in individuals with metabolic syndrome to appropriately target intensity of treatment for underlying CHD risk factors. American Diabetes Association 2008-07 /pmc/articles/PMC2453646/ /pubmed/18375418 http://dx.doi.org/10.2337/dc07-2087 Text en Copyright © 2008, American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Cardiovascular and Metabolic Risk
Hoang, Khiet C.
Ghandehari, Heli
Lopez, Victor A.
Barboza, Michael G.
Wong, Nathan D.
Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.
title Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.
title_full Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.
title_fullStr Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.
title_full_unstemmed Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.
title_short Global Coronary Heart Disease Risk Assessment of Individuals With the Metabolic Syndrome in the U.S.
title_sort global coronary heart disease risk assessment of individuals with the metabolic syndrome in the u.s.
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453646/
https://www.ncbi.nlm.nih.gov/pubmed/18375418
http://dx.doi.org/10.2337/dc07-2087
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