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Recent developments in the immunobiology of rheumatoid arthritis

Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T...

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Detalles Bibliográficos
Autores principales: Andersson, Anna K, Li, Ching, Brennan, Fionula M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453771/
https://www.ncbi.nlm.nih.gov/pubmed/18373887
http://dx.doi.org/10.1186/ar2370
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author Andersson, Anna K
Li, Ching
Brennan, Fionula M
author_facet Andersson, Anna K
Li, Ching
Brennan, Fionula M
author_sort Andersson, Anna K
collection PubMed
description Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies, and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis.
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spelling pubmed-24537712008-07-12 Recent developments in the immunobiology of rheumatoid arthritis Andersson, Anna K Li, Ching Brennan, Fionula M Arthritis Res Ther Review Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies, and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis. BioMed Central 2008 2008-03-14 /pmc/articles/PMC2453771/ /pubmed/18373887 http://dx.doi.org/10.1186/ar2370 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Review
Andersson, Anna K
Li, Ching
Brennan, Fionula M
Recent developments in the immunobiology of rheumatoid arthritis
title Recent developments in the immunobiology of rheumatoid arthritis
title_full Recent developments in the immunobiology of rheumatoid arthritis
title_fullStr Recent developments in the immunobiology of rheumatoid arthritis
title_full_unstemmed Recent developments in the immunobiology of rheumatoid arthritis
title_short Recent developments in the immunobiology of rheumatoid arthritis
title_sort recent developments in the immunobiology of rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453771/
https://www.ncbi.nlm.nih.gov/pubmed/18373887
http://dx.doi.org/10.1186/ar2370
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