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A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients

INTRODUCTION: Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patients. METHODS: A total of 82 early RA patients (disease duration < 1 year)...

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Autores principales: Syversen, Silje W, Goll, Guro L, Haavardsholm, Espen A, Bøyesen, Pernille, Lea, Tor, Kvien, Tore K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453772/
https://www.ncbi.nlm.nih.gov/pubmed/18312691
http://dx.doi.org/10.1186/ar2381
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author Syversen, Silje W
Goll, Guro L
Haavardsholm, Espen A
Bøyesen, Pernille
Lea, Tor
Kvien, Tore K
author_facet Syversen, Silje W
Goll, Guro L
Haavardsholm, Espen A
Bøyesen, Pernille
Lea, Tor
Kvien, Tore K
author_sort Syversen, Silje W
collection PubMed
description INTRODUCTION: Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patients. METHODS: A total of 82 early RA patients (disease duration < 1 year) were followed for 12 months. Clinical assessments, X-rays of hands and magnetic resonance imaging (MRI) of the dominant wrist were assessed at baseline and after 3, 6 and 12 months. The X-rays were scored according to the van der Heijde modified Sharp score (vdHSS). Cytokine analyses were performed with multiplex technology. Associations between cytokines and radiographic progression were examined by logistic regression. RESULTS: In all, 49% of the patients developed radiographic progression. The median (interquartile range (IQR)) baseline eotaxin level (pg/ml) was significantly lower in patients with (193 (119 to 247)) than without progression (265 (166 to 360)). In the univariate logistic regression analyses, eotaxin was negatively associated to radiographic progression, and this association was maintained in the multivariate model with an odds ratio (OR) (95% confidence interval (CI)) for progression of 0.58 (0.41 to 0.82) per 50 pg/ml increase in eotaxin level. None of the other measured cytokines showed any association to radiographic progression. CONCLUSION: This study raises the hypothesis that high serum levels of eotaxin predict less radiographic progression in early RA patients.
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spelling pubmed-24537722008-07-12 A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients Syversen, Silje W Goll, Guro L Haavardsholm, Espen A Bøyesen, Pernille Lea, Tor Kvien, Tore K Arthritis Res Ther Research Article INTRODUCTION: Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patients. METHODS: A total of 82 early RA patients (disease duration < 1 year) were followed for 12 months. Clinical assessments, X-rays of hands and magnetic resonance imaging (MRI) of the dominant wrist were assessed at baseline and after 3, 6 and 12 months. The X-rays were scored according to the van der Heijde modified Sharp score (vdHSS). Cytokine analyses were performed with multiplex technology. Associations between cytokines and radiographic progression were examined by logistic regression. RESULTS: In all, 49% of the patients developed radiographic progression. The median (interquartile range (IQR)) baseline eotaxin level (pg/ml) was significantly lower in patients with (193 (119 to 247)) than without progression (265 (166 to 360)). In the univariate logistic regression analyses, eotaxin was negatively associated to radiographic progression, and this association was maintained in the multivariate model with an odds ratio (OR) (95% confidence interval (CI)) for progression of 0.58 (0.41 to 0.82) per 50 pg/ml increase in eotaxin level. None of the other measured cytokines showed any association to radiographic progression. CONCLUSION: This study raises the hypothesis that high serum levels of eotaxin predict less radiographic progression in early RA patients. BioMed Central 2008 2008-03-02 /pmc/articles/PMC2453772/ /pubmed/18312691 http://dx.doi.org/10.1186/ar2381 Text en Copyright © 2008 Syversen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Syversen, Silje W
Goll, Guro L
Haavardsholm, Espen A
Bøyesen, Pernille
Lea, Tor
Kvien, Tore K
A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
title A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
title_full A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
title_fullStr A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
title_full_unstemmed A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
title_short A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
title_sort high serum level of eotaxin (ccl 11) is associated with less radiographic progression in early rheumatoid arthritis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453772/
https://www.ncbi.nlm.nih.gov/pubmed/18312691
http://dx.doi.org/10.1186/ar2381
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