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Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan....
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464726/ https://www.ncbi.nlm.nih.gov/pubmed/19943139 http://dx.doi.org/10.1007/s11357-006-9009-5 |
| Sumario: | Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed. |
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