Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice

Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan....

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Detalles Bibliográficos
Autor principal: Sun, Liou Y.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464726/
https://www.ncbi.nlm.nih.gov/pubmed/19943139
http://dx.doi.org/10.1007/s11357-006-9009-5
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author Sun, Liou Y.
author_facet Sun, Liou Y.
author_sort Sun, Liou Y.
collection PubMed
description Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.
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spelling pubmed-24647262008-08-28 Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice Sun, Liou Y. Age (Dordr) Article Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed. Springer Netherlands 2006-06-13 2006-06 /pmc/articles/PMC2464726/ /pubmed/19943139 http://dx.doi.org/10.1007/s11357-006-9009-5 Text en © Springer Science + Business Media B.V. 2006
spellingShingle Article
Sun, Liou Y.
Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
title Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
title_full Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
title_fullStr Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
title_full_unstemmed Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
title_short Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
title_sort hippocampal igf-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464726/
https://www.ncbi.nlm.nih.gov/pubmed/19943139
http://dx.doi.org/10.1007/s11357-006-9009-5
work_keys_str_mv AT sunliouy hippocampaligf1expressionneurogenesisandslowedagingcluestolongevityfrommutantmice

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