Positional Cloning of “Lisch-like”, a Candidate Modifier of Susceptibility to Type 2 Diabetes in Mice

In 404 Lep(ob/ob) F2 progeny of a C57BL/6J (B6) x DBA/2J (DBA) intercross, we mapped a DBA-related quantitative trait locus (QTL) to distal Chr1 at 169.6 Mb, centered about D1Mit110, for diabetes-related phenotypes that included blood glucose, HbA1c, and pancreatic islet histology. The interval was...

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Detalles Bibliográficos
Autores principales: Dokmanovic-Chouinard, Marija, Chung, Wendy K., Chevre, Jean-Claude, Watson, Elizabeth, Yonan, Jason, Wiegand, Beebe, Bromberg, Yana, Wakae, Nao, Wright, Chris V., Overton, John, Ghosh, Sujoy, Sathe, Ganesh M., Ammala, Carina E., Brown, Kathleen K., Ito, Rokuro, LeDuc, Charles, Solomon, Keely, Fischer, Stuart G., Leibel, Rudolph L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464733/
https://www.ncbi.nlm.nih.gov/pubmed/18654634
http://dx.doi.org/10.1371/journal.pgen.1000137

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