Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice

Saposin B derives from the multi-functional precursor, prosaposin, and functions as an activity enhancer for several glycosphingolipid (GSL) hydrolases. Mutations in saposin B present in humans with phenotypes resembling metachromatic leukodystrophy. To gain insight into saposin B's physiologic...

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Detalles Bibliográficos
Autores principales: Sun, Ying, Witte, David P., Ran, Huimin, Zamzow, Matt, Barnes, Sonya, Cheng, Hua, Han, Xianlin, Williams, Michael T., Skelton, Matthew R., Vorhees, Charles V., Grabowski, Gregory A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465797/
https://www.ncbi.nlm.nih.gov/pubmed/18480170
http://dx.doi.org/10.1093/hmg/ddn135

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