Molecular dissection of ALS-associated toxicity of SOD1 in transgenic mice using an exon-fusion approach

Mutations in Cu,Zn superoxide dismutase (SOD1) are associated with amyotrophic lateral sclerosis (ALS). Among more than 100 ALS-associated SOD1 mutations, premature termination codon (PTC) mutations exclusively occur in exon 5, the last exon of SOD1. The molecular basis of ALS-associated toxicity of...

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Autores principales: Han-Xiang, Deng, Hujun, Jiang, Ronggen, Fu, Hong, Zhai, Yong, Shi, Erdong, Liu, Makito, Hirano, Mauro, C. Dal Canto, Teepu, Siddique
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465800/
https://www.ncbi.nlm.nih.gov/pubmed/18424447
http://dx.doi.org/10.1093/hmg/ddn131

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