Genetics of focal segmental glomerulosclerosis

The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are...

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Detalles Bibliográficos
Autores principales: Woroniecki, Robert P., Kopp, Jeffrey B.
Formato: Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2007
Materias:
Educational Feature
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467504/
https://www.ncbi.nlm.nih.gov/pubmed/17347836
http://dx.doi.org/10.1007/s00467-007-0445-y
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author Woroniecki, Robert P.
Kopp, Jeffrey B.
author_facet Woroniecki, Robert P.
Kopp, Jeffrey B.
author_sort Woroniecki, Robert P.
collection PubMed
description The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic studies. Those genes and proteins interactions seem to change susceptibility to kidney disease progression. Better understanding of their exact role in the development of FSGS may influence future therapies and outcomes in this complex disease.
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spelling pubmed-24675042008-07-16 Genetics of focal segmental glomerulosclerosis Woroniecki, Robert P. Kopp, Jeffrey B. Pediatr Nephrol Educational Feature The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic studies. Those genes and proteins interactions seem to change susceptibility to kidney disease progression. Better understanding of their exact role in the development of FSGS may influence future therapies and outcomes in this complex disease. Springer Berlin Heidelberg 2007-05-01 2007 /pmc/articles/PMC2467504/ /pubmed/17347836 http://dx.doi.org/10.1007/s00467-007-0445-y Text en © IPNA 2007 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Educational Feature
Woroniecki, Robert P.
Kopp, Jeffrey B.
Genetics of focal segmental glomerulosclerosis
title Genetics of focal segmental glomerulosclerosis
title_full Genetics of focal segmental glomerulosclerosis
title_fullStr Genetics of focal segmental glomerulosclerosis
title_full_unstemmed Genetics of focal segmental glomerulosclerosis
title_short Genetics of focal segmental glomerulosclerosis
title_sort genetics of focal segmental glomerulosclerosis
topic Educational Feature
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467504/
https://www.ncbi.nlm.nih.gov/pubmed/17347836
http://dx.doi.org/10.1007/s00467-007-0445-y
work_keys_str_mv AT woronieckirobertp geneticsoffocalsegmentalglomerulosclerosis
AT koppjeffreyb geneticsoffocalsegmentalglomerulosclerosis

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