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Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

Human cytochrome P450 46A1 (CYP46A1) is one of the key enzymes in cholesterol homeostasis in the brain. The crystallization and heavy-atom structure solution of an active truncated CYP46A1 in complex with the high-affinity substrate analogue cholesterol-3-sulfate (CH-3S) is reported. The 2.6 Å struc...

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Detalles Bibliográficos
Autores principales:	White, Mark Andrew, Mast, Natalia, Bjorkhem, Ingemar, Johnson, Eric F., Stout, C. David, Pikuleva, Irina A.
Formato:	Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2008
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467524/ https://www.ncbi.nlm.nih.gov/pubmed/18453684 http://dx.doi.org/10.1107/S0907444908004046

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