Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2 (extracellular-signal-regulated kinase 1/2) in vitro and in vivo. DUSP6/MKP-3 is inducible by FGF (fibroblast growth factor) signalling and acts as a ne...

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Detalles Bibliográficos
Autores principales: Ekerot, Maria, Stavridis, Marios P., Delavaine, Laurent, Mitchell, Michael P., Staples, Christopher, Owens, David M., Keenan, Iain D., Dickinson, Robin J., Storey, Kate G., Keyse, Stephen M.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474557/
https://www.ncbi.nlm.nih.gov/pubmed/18321244
http://dx.doi.org/10.1042/BJ20071512

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