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A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report
INTRODUCTION: Influenza virus-associated encephalitis/encephalopathy is a severe childhood illness with a poor prognosis. Adult case reports are rare and, to date, there have been no reports of adults with a mild subcortical encephalopathy with reversible lesions of the corpus callosum splenium. CAS...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474850/ https://www.ncbi.nlm.nih.gov/pubmed/18588700 http://dx.doi.org/10.1186/1752-1947-2-220 |
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author | Kimura, En Okamoto, Sadahisa Uchida, Yuji Hirahara, Tomoo Ikeda, Tokunori Hirano, Teruyuki Uchino, Makoto |
author_facet | Kimura, En Okamoto, Sadahisa Uchida, Yuji Hirahara, Tomoo Ikeda, Tokunori Hirano, Teruyuki Uchino, Makoto |
author_sort | Kimura, En |
collection | PubMed |
description | INTRODUCTION: Influenza virus-associated encephalitis/encephalopathy is a severe childhood illness with a poor prognosis. Adult case reports are rare and, to date, there have been no reports of adults with a mild subcortical encephalopathy with reversible lesions of the corpus callosum splenium. CASE PRESENTATION: A previously healthy 35-year-old man presented with acute progressive tetraplegia, transcortical motor aphasia and a mild decrease in his consciousness during his recovery after receiving oseltamivir phosphate treatment, and influenza type A antiviral medication. The initial magnetic resonance imaging study at day 1 showed symmetrical diffuse lesions in the white matter and a lesion on the central portion of the corpus callosum splenium. These findings had resolved on follow-up studies at day 8 and day 146. His neurological deficits mostly recovered within 12 hours following methylprednisolone pulse therapy. The levels of interleukin-6 and interleukin-10 in his blood and cerebrospinal fluid were initially elevated, but rapidly decreased to normal levels by day 8. CONCLUSION: It is important for clinicians to recognize that even in adulthood, the subcortical encephalopathy observed during the therapeutic treatment for influenza type A infection can occur in conjunction with a reversible lesion of the corpus callosum, which may recover quickly. In addition, the cytokine storm in the blood system and the corticospinal cavity may play an important role in the etiology of the disease process. |
format | Text |
id | pubmed-2474850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24748502008-07-19 A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report Kimura, En Okamoto, Sadahisa Uchida, Yuji Hirahara, Tomoo Ikeda, Tokunori Hirano, Teruyuki Uchino, Makoto J Med Case Reports Case Report INTRODUCTION: Influenza virus-associated encephalitis/encephalopathy is a severe childhood illness with a poor prognosis. Adult case reports are rare and, to date, there have been no reports of adults with a mild subcortical encephalopathy with reversible lesions of the corpus callosum splenium. CASE PRESENTATION: A previously healthy 35-year-old man presented with acute progressive tetraplegia, transcortical motor aphasia and a mild decrease in his consciousness during his recovery after receiving oseltamivir phosphate treatment, and influenza type A antiviral medication. The initial magnetic resonance imaging study at day 1 showed symmetrical diffuse lesions in the white matter and a lesion on the central portion of the corpus callosum splenium. These findings had resolved on follow-up studies at day 8 and day 146. His neurological deficits mostly recovered within 12 hours following methylprednisolone pulse therapy. The levels of interleukin-6 and interleukin-10 in his blood and cerebrospinal fluid were initially elevated, but rapidly decreased to normal levels by day 8. CONCLUSION: It is important for clinicians to recognize that even in adulthood, the subcortical encephalopathy observed during the therapeutic treatment for influenza type A infection can occur in conjunction with a reversible lesion of the corpus callosum, which may recover quickly. In addition, the cytokine storm in the blood system and the corticospinal cavity may play an important role in the etiology of the disease process. BioMed Central 2008-06-28 /pmc/articles/PMC2474850/ /pubmed/18588700 http://dx.doi.org/10.1186/1752-1947-2-220 Text en Copyright © 2008 Kimura et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kimura, En Okamoto, Sadahisa Uchida, Yuji Hirahara, Tomoo Ikeda, Tokunori Hirano, Teruyuki Uchino, Makoto A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
title | A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
title_full | A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
title_fullStr | A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
title_full_unstemmed | A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
title_short | A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
title_sort | reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474850/ https://www.ncbi.nlm.nih.gov/pubmed/18588700 http://dx.doi.org/10.1186/1752-1947-2-220 |
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