Cargando…

Transduodenal excision of ampullary tumours.

The commonly recommended treatment for ampullary tumours--pancreaticoduodenectomy results in significant morbidity and mortality. This study is a retrospective evaluation of the procedure of transduodenal local excision of ampullary tumours. Demographics, symptoms, histological findings and outcomes...

Descripción completa

Detalles Bibliográficos
Autores principales: Bohra, A. K., McKie, L., Diamond, T.
Formato: Texto
Lenguaje:English
Publicado: Ulster Medical Society 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475303/
https://www.ncbi.nlm.nih.gov/pubmed/12513008
_version_ 1782157516914819072
author Bohra, A. K.
McKie, L.
Diamond, T.
author_facet Bohra, A. K.
McKie, L.
Diamond, T.
author_sort Bohra, A. K.
collection PubMed
description The commonly recommended treatment for ampullary tumours--pancreaticoduodenectomy results in significant morbidity and mortality. This study is a retrospective evaluation of the procedure of transduodenal local excision of ampullary tumours. Demographics, symptoms, histological findings and outcomes were retrospectively analysed in 15 patients. Survival analysis was done by the method of Kaplan-Meier and log-rank test. The median age was 68 years (range 54-78). Endoscopic biopsy was accurate in only 41% of cases. CT scan demonstrated a mass in 50% cases. Definitive histology reported 4 adenomas, 2 carcinomas-in-situ and 9 adenocarcinomas. Median hospital stay was 13 days. There was no operative mortality. Mean duration of follow-up was 31 months (range 7-70 months). The procedure appears curative for adenomas and in-situ carcinoma. Overall 3 year actuarial survival for ampullary tumours is 65% while that for moderately differentiated carcinomas is 50%. Pre-operative investigations provide inadequate histological information. Wide local excision is a safe operation with low morbidity and good survival in carefully selected cases. However, the role of local excision for carcinoma appears to be palliative rather than curative.
format Text
id pubmed-2475303
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher Ulster Medical Society
record_format MEDLINE/PubMed
spelling pubmed-24753032008-07-22 Transduodenal excision of ampullary tumours. Bohra, A. K. McKie, L. Diamond, T. Ulster Med J Research Article The commonly recommended treatment for ampullary tumours--pancreaticoduodenectomy results in significant morbidity and mortality. This study is a retrospective evaluation of the procedure of transduodenal local excision of ampullary tumours. Demographics, symptoms, histological findings and outcomes were retrospectively analysed in 15 patients. Survival analysis was done by the method of Kaplan-Meier and log-rank test. The median age was 68 years (range 54-78). Endoscopic biopsy was accurate in only 41% of cases. CT scan demonstrated a mass in 50% cases. Definitive histology reported 4 adenomas, 2 carcinomas-in-situ and 9 adenocarcinomas. Median hospital stay was 13 days. There was no operative mortality. Mean duration of follow-up was 31 months (range 7-70 months). The procedure appears curative for adenomas and in-situ carcinoma. Overall 3 year actuarial survival for ampullary tumours is 65% while that for moderately differentiated carcinomas is 50%. Pre-operative investigations provide inadequate histological information. Wide local excision is a safe operation with low morbidity and good survival in carefully selected cases. However, the role of local excision for carcinoma appears to be palliative rather than curative. Ulster Medical Society 2002-11 /pmc/articles/PMC2475303/ /pubmed/12513008 Text en
spellingShingle Research Article
Bohra, A. K.
McKie, L.
Diamond, T.
Transduodenal excision of ampullary tumours.
title Transduodenal excision of ampullary tumours.
title_full Transduodenal excision of ampullary tumours.
title_fullStr Transduodenal excision of ampullary tumours.
title_full_unstemmed Transduodenal excision of ampullary tumours.
title_short Transduodenal excision of ampullary tumours.
title_sort transduodenal excision of ampullary tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475303/
https://www.ncbi.nlm.nih.gov/pubmed/12513008
work_keys_str_mv AT bohraak transduodenalexcisionofampullarytumours
AT mckiel transduodenalexcisionofampullarytumours
AT diamondt transduodenalexcisionofampullarytumours