Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach

BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falciparum infection prevalence were examined among schoolchildren in a highly malaria-endemic area. METHO...

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Autores principales: Silué, Kigbafori D, Raso, Giovanna, Yapi, Ahoua, Vounatsou, Penelope, Tanner, Marcel, N'Goran, Eliézer K, Utzinger, Jürg
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475523/
https://www.ncbi.nlm.nih.gov/pubmed/18570685
http://dx.doi.org/10.1186/1475-2875-7-111
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author Silué, Kigbafori D
Raso, Giovanna
Yapi, Ahoua
Vounatsou, Penelope
Tanner, Marcel
N'Goran, Eliézer K
Utzinger, Jürg
author_facet Silué, Kigbafori D
Raso, Giovanna
Yapi, Ahoua
Vounatsou, Penelope
Tanner, Marcel
N'Goran, Eliézer K
Utzinger, Jürg
author_sort Silué, Kigbafori D
collection PubMed
description BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falciparum infection prevalence were examined among schoolchildren in a highly malaria-endemic area. METHODS: A questionnaire was administered and finger prick blood samples collected from 3,962 children, aged six to 16 years, attending 55 schools in a rural part of western Côte d'Ivoire. Information was gathered from the questionnaire on children's socioeconomic status and the use of bed nets for the prevention of malaria. Blood samples were processed with standardized, quality-controlled methods for diagnosis of Plasmodium spp. infections. Environmental data were obtained from satellite images and digitized maps. Bayesian variogram models for spatially-explicit risk modelling of P. falciparum infection prevalence were employed, assuming for stationary and non-stationary spatial processes. FINDINGS: The overall prevalence of P. falciparum infection was 64.9%, ranging between 34.0% and 91.9% at the unit of the school. Risk factors for a P. falciparum infection included age, socioeconomic status, not sleeping under a bed net, distance to health care facilities and a number of environmental features (i.e. normalized difference vegetation index, rainfall and distance to rivers). After taking into account spatial correlation only age remained significant. Non-stationary models performed better than stationary models. CONCLUSION: Spatial risk profiling of P. falciparum prevalence data provides a useful tool for targeting malaria control intervention, and hence will play a role in the quest of local elimination and ultimate eradication of the disease.
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spelling pubmed-24755232008-07-21 Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach Silué, Kigbafori D Raso, Giovanna Yapi, Ahoua Vounatsou, Penelope Tanner, Marcel N'Goran, Eliézer K Utzinger, Jürg Malar J Research BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falciparum infection prevalence were examined among schoolchildren in a highly malaria-endemic area. METHODS: A questionnaire was administered and finger prick blood samples collected from 3,962 children, aged six to 16 years, attending 55 schools in a rural part of western Côte d'Ivoire. Information was gathered from the questionnaire on children's socioeconomic status and the use of bed nets for the prevention of malaria. Blood samples were processed with standardized, quality-controlled methods for diagnosis of Plasmodium spp. infections. Environmental data were obtained from satellite images and digitized maps. Bayesian variogram models for spatially-explicit risk modelling of P. falciparum infection prevalence were employed, assuming for stationary and non-stationary spatial processes. FINDINGS: The overall prevalence of P. falciparum infection was 64.9%, ranging between 34.0% and 91.9% at the unit of the school. Risk factors for a P. falciparum infection included age, socioeconomic status, not sleeping under a bed net, distance to health care facilities and a number of environmental features (i.e. normalized difference vegetation index, rainfall and distance to rivers). After taking into account spatial correlation only age remained significant. Non-stationary models performed better than stationary models. CONCLUSION: Spatial risk profiling of P. falciparum prevalence data provides a useful tool for targeting malaria control intervention, and hence will play a role in the quest of local elimination and ultimate eradication of the disease. BioMed Central 2008-06-23 /pmc/articles/PMC2475523/ /pubmed/18570685 http://dx.doi.org/10.1186/1475-2875-7-111 Text en Copyright © 2008 Silué et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Silué, Kigbafori D
Raso, Giovanna
Yapi, Ahoua
Vounatsou, Penelope
Tanner, Marcel
N'Goran, Eliézer K
Utzinger, Jürg
Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach
title Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach
title_full Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach
title_fullStr Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach
title_full_unstemmed Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach
title_short Spatially-explicit risk profiling of Plasmodium falciparum infections at a small scale: a geostatistical modelling approach
title_sort spatially-explicit risk profiling of plasmodium falciparum infections at a small scale: a geostatistical modelling approach
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475523/
https://www.ncbi.nlm.nih.gov/pubmed/18570685
http://dx.doi.org/10.1186/1475-2875-7-111
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