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Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos

S(N)1-type alkylating agents, like N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU), are potent mutagens. Exposure to alkylating agents gives rise to O(6)-alkylguanine, a modified base that is recognized by DNA mismatch repair (MMR) proteins but is not repairable, resulting in replicatio...

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Detalles Bibliográficos
Autores principales:	Feitsma, Harma, Akay, Alper, Cuppen, Edwin
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475609/ https://www.ncbi.nlm.nih.gov/pubmed/18522974 http://dx.doi.org/10.1093/nar/gkn341

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