Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

In mammalian cells, DNA double-strand breaks (DSBs) are repaired by three pathways, nonhomologous end-joining (NHEJ), gene conversion (GC) and single-strand annealing (SSA). These pathways are distinct with regard to repair efficiency and mutagenic potential and must be tightly controlled to preserv...

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Detalles Bibliográficos
Autores principales: Mansour, Wael Y., Schumacher, Sabine, Rosskopf, Raphael, Rhein, Tim, Schmidt-Petersen, Filip, Gatzemeier, Fruszina, Haag, Friedrich, Borgmann, Kerstin, Willers, Henning, Dahm-Daphi, Jochen
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475611/
https://www.ncbi.nlm.nih.gov/pubmed/18539610
http://dx.doi.org/10.1093/nar/gkn347

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