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Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity
Changing a highly conserved amino acid in motif A of any of the four yeast family B DNA polymerases, DNA polymerase α, δ, ɛ or ζ, results in yeast strains with elevated mutation rates. In order to better understand this phenotype, we have performed structure–function studies of homologous mutants of...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475618/ https://www.ncbi.nlm.nih.gov/pubmed/18503083 http://dx.doi.org/10.1093/nar/gkn312 |