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Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase

As a widely used anticancer drug, cis-diamminedichloroplatinum(II) (cisplatin) reacts with adjacent purine bases in DNA to form predominantly cis-[Pt(NH(3))(2){d(GpG)-N7(1),-N7(2)}] intrastrand cross-links. Drug resistance, one of the major limitations of cisplatin therapy, is partially due to the i...

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Detalles Bibliográficos
Autores principales:	Brown, Jessica A., Newmister, Sean A., Fiala, Kevin A., Suo, Zucai
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475632/ https://www.ncbi.nlm.nih.gov/pubmed/18499711 http://dx.doi.org/10.1093/nar/gkn309

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