Modulation of Voltage- and Ca(2+)-dependent Gating of Ca(V)1.3 L-type Calcium Channels by Alternative Splicing of a C-terminal Regulatory Domain

Low voltage activation of Ca(V)1.3 L-type Ca(2+) channels controls excitability in sensory cells and central neurons as well as sinoatrial node pacemaking. Ca(V)1.3-mediated pacemaking determines neuronal vulnerability of dopaminergic striatal neurons affected in Parkinson disease. We have previousl...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Anamika, Gebhart, Mathias, Fritsch, Reinhard, Sinnegger-Brauns, Martina J., Poggiani, Chiara, Hoda, Jean-Charles, Engel, Jutta, Romanin, Christoph, Striessnig, Jörg, Koschak, Alexandra
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475692/
https://www.ncbi.nlm.nih.gov/pubmed/18482979
http://dx.doi.org/10.1074/jbc.M802254200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475692/
https://www.ncbi.nlm.nih.gov/pubmed/18482979
http://dx.doi.org/10.1074/jbc.M802254200

Ejemplares similares