Cargando…
Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet
Restricted fetal growth is associated with increased risk for the future development of Type 2 diabetes in humans. The study aim was to assess the glucose tolerance of old (seventeen months) male rats, which were growth restricted in early life due to maternal protein restriction during gestation an...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2001
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478537/ https://www.ncbi.nlm.nih.gov/pubmed/12369717 http://dx.doi.org/10.1155/EDR.2001.139 |
_version_ | 1782157585795776512 |
---|---|
author | Petry, Clive J. Dorling, Matthew W. Pawlak, Dorota B. Ozanne, Susan E. Hales, C. Nicholas |
author_facet | Petry, Clive J. Dorling, Matthew W. Pawlak, Dorota B. Ozanne, Susan E. Hales, C. Nicholas |
author_sort | Petry, Clive J. |
collection | PubMed |
description | Restricted fetal growth is associated with increased risk for the future development of Type 2 diabetes in humans. The study aim was to assess the glucose tolerance of old (seventeen months) male rats, which were growth restricted in early life due to maternal protein restriction during gestation and lactation. Rat mothers were fed diets containing either 20% or 8% protein and all offspring weaned onto a standard rat diet. In old-age fasting plasma glucose concentrations were significantly higher in the low protein offspring: 8.4 (1.3)mmol/l v. 5.3 (1.3)mmol/l (p = 0.005), Areas under the curves were increased by 67% for glucose (p = 0.01) and 81% for insulin (p = 0.01) in these rats in intravenous glucose tolerance tests, suggesting (a degree of) insulin resistance. These results show that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring. The diabetes is predominantly associated with insulin resistance. |
format | Text |
id | pubmed-2478537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24785372008-08-18 Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet Petry, Clive J. Dorling, Matthew W. Pawlak, Dorota B. Ozanne, Susan E. Hales, C. Nicholas Int J Exp Diabetes Res Research Article Restricted fetal growth is associated with increased risk for the future development of Type 2 diabetes in humans. The study aim was to assess the glucose tolerance of old (seventeen months) male rats, which were growth restricted in early life due to maternal protein restriction during gestation and lactation. Rat mothers were fed diets containing either 20% or 8% protein and all offspring weaned onto a standard rat diet. In old-age fasting plasma glucose concentrations were significantly higher in the low protein offspring: 8.4 (1.3)mmol/l v. 5.3 (1.3)mmol/l (p = 0.005), Areas under the curves were increased by 67% for glucose (p = 0.01) and 81% for insulin (p = 0.01) in these rats in intravenous glucose tolerance tests, suggesting (a degree of) insulin resistance. These results show that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring. The diabetes is predominantly associated with insulin resistance. Hindawi Publishing Corporation 2001 /pmc/articles/PMC2478537/ /pubmed/12369717 http://dx.doi.org/10.1155/EDR.2001.139 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Petry, Clive J. Dorling, Matthew W. Pawlak, Dorota B. Ozanne, Susan E. Hales, C. Nicholas Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet |
title | Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet |
title_full | Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet |
title_fullStr | Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet |
title_full_unstemmed | Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet |
title_short | Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet |
title_sort | diabetes in old male offspring of rat dams fed a reduced protein diet |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478537/ https://www.ncbi.nlm.nih.gov/pubmed/12369717 http://dx.doi.org/10.1155/EDR.2001.139 |
work_keys_str_mv | AT petryclivej diabetesinoldmaleoffspringofratdamsfedareducedproteindiet AT dorlingmattheww diabetesinoldmaleoffspringofratdamsfedareducedproteindiet AT pawlakdorotab diabetesinoldmaleoffspringofratdamsfedareducedproteindiet AT ozannesusane diabetesinoldmaleoffspringofratdamsfedareducedproteindiet AT halescnicholas diabetesinoldmaleoffspringofratdamsfedareducedproteindiet |