Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse

Insulin secretion declines progressively before and during the course of type 2 diabetes. Evidence indicates that this process is, in part, secondary to increased requirement for insulin secretion that is brought about by insulin resistance and by hyperglycemia. The effects of over-secretion extend...

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Detalles Bibliográficos
Autores principales: Grill, Valdemar, Björklund, Anneli
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478581/
https://www.ncbi.nlm.nih.gov/pubmed/12458655
http://dx.doi.org/10.1080/15604280214276
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author Grill, Valdemar
Björklund, Anneli
author_facet Grill, Valdemar
Björklund, Anneli
author_sort Grill, Valdemar
collection PubMed
description Insulin secretion declines progressively before and during the course of type 2 diabetes. Evidence indicates that this process is, in part, secondary to increased requirement for insulin secretion that is brought about by insulin resistance and by hyperglycemia. The effects of over-secretion extend far beyond a mere reduction of available insulin stores and may cause not only functional but also structural damage. The time is ripe for clinical studies, which explore the therapeutic potential of reducing over-secretion.
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spelling pubmed-24785812008-08-18 Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse Grill, Valdemar Björklund, Anneli Int J Exp Diabetes Res Research Article Insulin secretion declines progressively before and during the course of type 2 diabetes. Evidence indicates that this process is, in part, secondary to increased requirement for insulin secretion that is brought about by insulin resistance and by hyperglycemia. The effects of over-secretion extend far beyond a mere reduction of available insulin stores and may cause not only functional but also structural damage. The time is ripe for clinical studies, which explore the therapeutic potential of reducing over-secretion. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2478581/ /pubmed/12458655 http://dx.doi.org/10.1080/15604280214276 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grill, Valdemar
Björklund, Anneli
Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse
title Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse
title_full Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse
title_fullStr Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse
title_full_unstemmed Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse
title_short Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse
title_sort type 2 diabetes—effect of compensatory oversecretion as a reason for β-cell collapse
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478581/
https://www.ncbi.nlm.nih.gov/pubmed/12458655
http://dx.doi.org/10.1080/15604280214276
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