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Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits: Role of Dietary Vitamin E Supplementation
Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control,...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478584/ https://www.ncbi.nlm.nih.gov/pubmed/12458660 http://dx.doi.org/10.1080/15604280214279 |
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author | Davis, Randall L. Lavine, Christy L. Arredondo, Melissa A. McMahon, Patrick Tenner, Jr., Thomas E. |
author_facet | Davis, Randall L. Lavine, Christy L. Arredondo, Melissa A. McMahon, Patrick Tenner, Jr., Thomas E. |
author_sort | Davis, Randall L. |
collection | PubMed |
description | Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. PlasmaLPOwas influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasmaLPOwas the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation. |
format | Text |
id | pubmed-2478584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24785842008-08-18 Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits: Role of Dietary Vitamin E Supplementation Davis, Randall L. Lavine, Christy L. Arredondo, Melissa A. McMahon, Patrick Tenner, Jr., Thomas E. Int J Exp Diabetes Res Research Article Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. PlasmaLPOwas influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasmaLPOwas the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation. Hindawi Publishing Corporation 2002 /pmc/articles/PMC2478584/ /pubmed/12458660 http://dx.doi.org/10.1080/15604280214279 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Davis, Randall L. Lavine, Christy L. Arredondo, Melissa A. McMahon, Patrick Tenner, Jr., Thomas E. Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits: Role of Dietary Vitamin E Supplementation |
title | Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits:
Role of Dietary Vitamin E Supplementation |
title_full | Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits:
Role of Dietary Vitamin E Supplementation |
title_fullStr | Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits:
Role of Dietary Vitamin E Supplementation |
title_full_unstemmed | Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits:
Role of Dietary Vitamin E Supplementation |
title_short | Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits:
Role of Dietary Vitamin E Supplementation |
title_sort | differential indicators of diabetes-induced oxidative stress in new zealand white rabbits:
role of dietary vitamin e supplementation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478584/ https://www.ncbi.nlm.nih.gov/pubmed/12458660 http://dx.doi.org/10.1080/15604280214279 |
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