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C-peptide and Central Nervous System Complications in Diabetes

Substantial evidence collected from clinical data and experimental studies has indicated that CNS is not spared from diabetes complications. Impairments in CNS function are well documented in both type 1 and type 2 diabetic patients as well as in various animal models of diabetes, in terms of altera...

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Autores principales: Li, Zhen-guo, Sima, Anders A. F.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478617/
https://www.ncbi.nlm.nih.gov/pubmed/15198373
http://dx.doi.org/10.1080/15438600490424550
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author Li, Zhen-guo
Sima, Anders A. F.
author_facet Li, Zhen-guo
Sima, Anders A. F.
author_sort Li, Zhen-guo
collection PubMed
description Substantial evidence collected from clinical data and experimental studies has indicated that CNS is not spared from diabetes complications. Impairments in CNS function are well documented in both type 1 and type 2 diabetic patients as well as in various animal models of diabetes, in terms of alterations in cognition, neuropsychology, neurobehavior, electrophysiology, structure, neurochemistry and apoptotic activities. These data suggest that primary diabetic encephalopathy exists as a definable diabetic complication. The mechanisms underlying this CNS complication are not clear. Experimental studies have suggested that neuronal apoptosis may play an important role in neuronal loss and impaired cognitive function. In diabetes multiple factors are responsible for neuronal apoptosis, such as a perturbed IGF system, hyperglycemia and the aging process itself. Recent data suggest that insulin/C-peptide deficiency may exert an eminent role. Administration of C-peptide partially corrects the perturbed IGF system in the brain and prevents neuronal apoptosis in hippocampus of type 1 diabetes. In neuroblastoma SH-SY5Y cells C-peptide provides a dose-dependent stimulation on cell proliferation and an anti-apoptotic effect as well. These studies provide a basis for administration of C-peptide as a potentially effective therapy for type 1 diabetes.
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spelling pubmed-24786172008-08-18 C-peptide and Central Nervous System Complications in Diabetes Li, Zhen-guo Sima, Anders A. F. Exp Diabesity Res Research Article Substantial evidence collected from clinical data and experimental studies has indicated that CNS is not spared from diabetes complications. Impairments in CNS function are well documented in both type 1 and type 2 diabetic patients as well as in various animal models of diabetes, in terms of alterations in cognition, neuropsychology, neurobehavior, electrophysiology, structure, neurochemistry and apoptotic activities. These data suggest that primary diabetic encephalopathy exists as a definable diabetic complication. The mechanisms underlying this CNS complication are not clear. Experimental studies have suggested that neuronal apoptosis may play an important role in neuronal loss and impaired cognitive function. In diabetes multiple factors are responsible for neuronal apoptosis, such as a perturbed IGF system, hyperglycemia and the aging process itself. Recent data suggest that insulin/C-peptide deficiency may exert an eminent role. Administration of C-peptide partially corrects the perturbed IGF system in the brain and prevents neuronal apoptosis in hippocampus of type 1 diabetes. In neuroblastoma SH-SY5Y cells C-peptide provides a dose-dependent stimulation on cell proliferation and an anti-apoptotic effect as well. These studies provide a basis for administration of C-peptide as a potentially effective therapy for type 1 diabetes. Hindawi Publishing Corporation 2004 /pmc/articles/PMC2478617/ /pubmed/15198373 http://dx.doi.org/10.1080/15438600490424550 Text en Copyright © 2004 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Zhen-guo
Sima, Anders A. F.
C-peptide and Central Nervous System Complications in Diabetes
title C-peptide and Central Nervous System Complications in Diabetes
title_full C-peptide and Central Nervous System Complications in Diabetes
title_fullStr C-peptide and Central Nervous System Complications in Diabetes
title_full_unstemmed C-peptide and Central Nervous System Complications in Diabetes
title_short C-peptide and Central Nervous System Complications in Diabetes
title_sort c-peptide and central nervous system complications in diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478617/
https://www.ncbi.nlm.nih.gov/pubmed/15198373
http://dx.doi.org/10.1080/15438600490424550
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